Research

Cosmelan Characteristics

Cosmelan® Depigmentation treatment guarantees the improvement of the anti-aesthetic skin blemishes with a very high safety margin.

Cosmelan® Depigmentation treatment’s principal action is the elimination of melanin patches on the face (melasma and chloasma).   The treatment involves a very versatile, dynamic process which is easily adapted to the needs of each individual patient.


Cosmelan® Depigmentation treatment action mechanism is based on the inhibition of tyrosinase, a basic enzyme in the melanin formation process. Several of the substances present in the Cosmelan® formula act by blocking this enzyme, or even by inverting the metabolic process of the transformation chain.

Melanogenesis comprises the following stages:

TYROSINE proceeds to DOPA by means of TYROSINASE.

DOPA proceeds to DOPAQUINONE by means of TYROSINASE.

DOPAQUINONE proceeds to PHAEOMELANINE and EUMELANIN by means of oxidation and cyclization.
 

Results In most cases, the disappearance of the blemishes improves tremendously.

ONE WEEK after starting the Cosmelan® Depigmentation treatment, a noticeable significant improvement of the skin is observed! The reduction of the treated blemish is detected and the appearance of new luminous and rejuvenated skin is present.

At the end of the Cosmelan® Depigmentation treatment, the blemishes start to disappear altogether, so that, although the patient may be able to “locate” the place where the spot was, the truth is that the pigmentation will have disappeared and nobody will be able to see it just by looking at it.
 

Active Ingredients - Cosmelan® Pack

Degreasing Solution
Aqua, Acetone

Cosmelan® 1 - Cream (10g)
Azelaic Acid, Kojic Acid, Phytic Acid, Ascorbic Acid, Arbutine, Titanium Dioxide

Cosmelan® 2 – Maintenance Cream (30g)
Titanium Dioxide, Kojic Acid, Phytic Acid, Ascorbic Acid

mesoestetic® Hydra Vital Factor K Cream (50ml)
Hydro nutritional cream for face and neck. Hydroviton, VItamin K, Vitamin E, Amniotic fluid, Glycerine, Silicone oil.



Preliminary Information for the Patient

Important: it must be known if the patient has undergone any previous treatments, especially with glycolic acid. If confirmed, any treatment, especially Glycolic Acid, must be eliminated at least, one week prior to using Cosmelan® Depigmentation treatment.

The Cosmelan® Depigmentation treatment initiated at the medical office must be continued at home, on a daily basis, according to the guidelines indicated.

The treatment must not be interrupted under any circumstances, during the whole time prescribed.

It is completely forbidden to combine the Cosmelan® Depigmentation treatment with other depigmentation treatments, as the appearance of undesired effects cannot be guaranteed.

Follow up visits are recommended 15 days after the beginning of treatment, and 30 days after, and a follow up treatment are revisit every month thereafter.



Treatment Application - Cosmelan® Depigmentation Treatment

Application of Degreasing Solution
• Clean skin with water and neutral cleanser.

• Apply Degreasing solution to the whole area to be treated. It will eliminate all impurities and oil from the skin to achieve optimum penetration of Cosmelan® 1 - Cream

Application of Cosmelan® 1 – Cream

• Evenly distribute the cream to form a facemask, applying a thicker layer over blemishes gradually thinning out over the rest of the face.

• The patient goes home with the mask applied based on the Fitzpatrick photo type classification suggested below:

• After the action time has elapsed, the patient must remove the mask with water and a neutral cleanser.

• Following, the patient will apply a layer of mesoestetic® Hydra Vital Factor K Cream over the whole surface treated.


Evolution After Cosmelan 1

First and Second day

• During the first two days of the treatment, the skin may turn red.

• If the skin is very sensitive, the patient may experience an itching feeling.

• Slight burning and tightening of the skin is also absolutely normal, especially during the first 24 to 48 hours after starting the treatment.

• To relieve these problems, it is advisable to apply the mesoestetic® Hydra-vital factor K whenever necessary.

Reddening of the Skin

The reddening that occurs on the face after applying the mesoestetic® Cosmelan 1 treatment is similar to the effects of day-long exposure to the sun in the snow without protection. (Intense reddening in photo type I and II and practically non existent in photo type IV and V)

Flaking

Flaking may occur on all skin types (and more intensely in photo types I and II) between the second and third day. In this case it is advisable to apply the mesoestetic® Hydra-vital factor K cream, repeating this every two hours on the day when the flaking is most intense.

Third and Fourth day

After the third or fourth day, the skin appears healthy and luminous and the marks begin to fade.

Home Treatment - Cosmelan® 2 Maintenance Cream

• Clean Face completely, every time mesoestetic® Cosmelan 2 is applied.

• Apply a thin layer of mesoestetic® Cosmelan 2 all over face mask style, with a light, circular movement.

• Apply mesoestetic® Hydra-vital factor K to the face and neck with a light, circular motion 15 minutes after applying mesoestetic® Cosmelan 2. Use daily.